The Most Recent Insights into the Roots of Gastric Cancer.

ABSTRACT: Helicobacter pylori (H. pylori) is the most common bacterial infection worldwide, usually being acquired during childhood, and its persistence into adulthood represents one of the main contributors of gastric carcinogenesis. Based on these statements, it would be of great importance to know if the most early premalignant transformation occurs in children or later since, this would enable the development of effective anti-tumorigenesis strategies. The interplay between H. pylori virulence factors, the host's responses modified by this infection, and the gastric microecology are complex and eventually lead to the development of gastric cancer in susceptible individuals. Several biomarkers were identified as major contributors of this long-lasting process, such as pepsino

SUBMITTER: Melit LE 

PROVIDER: S-EPMC10817233 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature