Exploring the Potential of Exosomal Biomarkers in Mild Traumatic Brain Injury and Post-Concussion Syndrome: A Systematic Review.

ABSTRACT:

Background

Alongside their long-term effects, post-concussion syndrome (PCS) and mild traumatic brain injuries (mTBI) are significant public health concerns. Currently, there is a lack of reliable biomarkers for diagnosing and monitoring mTBI and PCS. Exosomes are small extracellular vesicles secreted by cells that have recently emerged as a potential source of biomarkers for mTBI and PCS due to their ability to cross the blood-brain barrier and reflect the pathophysiology of brain injury. In this study, we aimed to investigate the role of salivary exosomal biomarkers in mTBI and PCS.

Methods

A systematic review using the PRISMA guidelines was conducted, and studies were selected based on their relevance to the topic.

Results

The analyzed studies have shown that exoso

SUBMITTER: Mavroudis I 

PROVIDER: S-EPMC10817245 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature