A novel disulfidptosis-related lncRNAs signature for predicting survival and immune response in hepatocellular carcinoma.

ABSTRACT: The accumulation of intracellular disulfides induces a novel and unique form of metabolic-related cell death known as disulfidptosis. A previous study revealed the prognostic value of a risk model of disulfidptosis-related genes in hepatocellular carcinoma (HCC). However, to date, no studies have investigated the relationship between disulfidptosis-related long non-coding RNAs (DRLs) and HCC. In this study, we collected and analyzed RNA sequencing data from 370 HCC samples to explore the DRLs in the tumorigenesis and development of HCC. By employing Lasso Cox regression and multivariate Cox regression analyses, we identified five prognostic DRLs, which were used to construct a prognostic signature. The signature was subsequently validated using receiver operating characteristic (ROC) curve

SUBMITTER: Guo Z 

PROVIDER: S-EPMC10817373 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature