High expression of integrin-binding sialoprotein (IBSP) is associated with poor prognosis of osteosarcoma.

ABSTRACT:

Introduction

Osteosarcoma is a malignant tumor, accounting for 20% of primary malignant bone tumors worldwide. However, the role of IBSP as a biomarker in osteosarcoma progression has not been studied yet.

Methods

85 cases of IBSP expression and clinical characteristics were obtained from TARGET database. Through the Kaplan-Meier curve, subgroup analysis, and univariate and multivariate Cox analysis, we further assessed the independent predictive capacity of IBSP expression for overall survival (OS) and relapse-free survival (RFS).

Results

The mRNA expression of IBSP was higher in osteosarcoma than normal tissue (P < 0.0001). IBSP expression grouped by vital status showed statistical differences (P = 0.042). The race (P = 0.0183), vital status (

SUBMITTER: Ma Y 

PROVIDER: S-EPMC10817378 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature