Identification of immune-related genes and integrated analysis of immune-cell infiltration in melanoma.

ABSTRACT:

Objective

This study was conducted to screen out immune-related genes in connection with the prognosis of melanoma, construct a prognosis model and explore the relevant mechanisms.

Methods and materials

1973 genes associated with immune system were derived from the Immport database, and RNA-seq data of melanoma and information of patients were searched from the Xena database. Cox univariate analysis, Lasso analysis and Cox multivariate analysis were used to screen out six genes to construct the model. Then the risk scores were estimated for patients based on our constructed prognosis model. Estimate was used to affirm that the model was about immune infiltration, and CIBERSORT was used to screen out immune cells associated with prognosis. TIDE was applied to predict the effi

SUBMITTER: He Z 

PROVIDER: S-EPMC10817386 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature