LAMP3 is a potent uterine corpus endometrial carcinoma prognostic biomarker associated with immune behavior.

ABSTRACT:

Background

Uterine corpus endometrial carcinoma (UCEC) is one of the most common gynecological malignancies and its incidence and mortality continue apace. Lysosome-associated membrane protein 3 (LAMP3) is the third member of the LAMP family and its overexpression has been described to be involved in the progression of breast, ovarian and cervical cancers, but there has been an absence of research focusing on its role in UCEC.

Methods

WGCNA, TIMER, LinkedOmics, GSEA, Cytoscape, Kaplan-Meier plotter, GDC, GeneMANIA, cBioPortal, PDB, RNAinter, miRNet were applied in this research.

Results

Our study uncovers that LAMP3 possesses higher expression levels in UCEC compared to normal tissues, and this differential expression profile is tightly aligned with clinical and patho

SUBMITTER: Fu B 

PROVIDER: S-EPMC10817406 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature