Genetic support of the causal association between gut microbiota and peripheral artery disease: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

The causal relationship between gut microbiota and peripheral artery disease (PAD) is still not clear. In this research, we employed the Mendelian randomization (MR) technique to explore the potential causal connection between 211 gut microbiota species and PAD. We also investigated whether the causal effects operate in both directions.

Methods

We used Genome-wide Association Studies (GWAS) summary statistics data from the MiBioGen and FinnGen consortia to conduct a two-sample MR analysis to explore the causal link between gut microbiota and PAD. Sensitivity analysis is conducted to assess the robustness of the MR results. In addition to that, reverse MR analysis was performed to examine the inverse causal relationship.

Results

The inverse variance weighted

SUBMITTER: Shi H 

PROVIDER: S-EPMC10817407 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature