Nutlin-3 Loaded Ethosomes and Transethosomes to Prevent UV-Associated Skin Damage.

ABSTRACT: The skin's protective mechanisms, in some cases, are not able to counteract the destructive effects induced by UV radiations, resulting in dermatological diseases, as well as skin aging. Nutlin-3, a potent drug with antiproliferative activity in keratinocytes, can block UV-induced apoptosis by activation of p53. In the present investigation, ethosomes and transethosomes were designed as delivery systems for nutlin-3, with the aim to protect the skin against UV damage. Vesicle size distribution was evaluated by photon correlation spectroscopy and morphology was investigated by cryogenic transmission electron microscopy, while nutlin-3 entrapment capacity was evaluated by ultrafiltration and HPLC. The in vitro diffusion kinetic of nutlin-3 from ethosomes and transethosomes was studied by Fra

SUBMITTER: Esposito E 

PROVIDER: S-EPMC10817472 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature