Design of a Multi-Epitope Vaccine against Histoplasma capsulatum through Immunoinformatics Approaches.

ABSTRACT: Histoplasmosis is a widespread systemic disease caused by Histoplasma capsulatum, prevalent in the Americas. Despite its significant morbidity and mortality rates, no vaccines are currently available. Previously, five vaccine targets and specific epitopes for H. capsulatum were identified. Immunoinformatics has emerged as a novel approach for determining the main immunogenic components of antigens through in silico methods. Therefore, we predicted the main helper and cytotoxic T lymphocytes and B-cell epitopes for these targets to create a potential multi-epitope vaccine known as HistoVAC-TSFM. A total of 38 epitopes were found: 23 common to CTL and B-cell responses, 11 linked to HTL and B cells, and 4 previously validated epitopes associated with the B subunit of cholera tox

SUBMITTER: Marques PH 

PROVIDER: S-EPMC10817582 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature