Impact of ferroptosis-related risk genes on macrophage M1/M2 polarization and prognosis in glioblastoma.

ABSTRACT:

Objective

To explore the effect impact of ferroptosis on macrophage polarization and patient prognosis in glioblastoma.

Methods

We screened ferroptosis-related risk from the public datasets of primary and recurrent glioblastoma, combined with reported ferroptosis genes, calculated the risk genes among the ferroptosis-related genes using the LASSO Cox regression model, and investigated the relationship between these ferroptosis-related risk genes in the tumor and the spectrum of infiltrating M1/M2 macrophages. Macrophages were analyzed using the CIBERSORTx deconvolution algorithm. Samples from The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA) and a single-cell RNA sequencing dataset (GSE84465) were included. The expression levels of ferroptosis-related risk g

SUBMITTER: Xu X 

PROVIDER: S-EPMC10817728 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature