Long-term cisplatin nephrotoxicity after childhood cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Cisplatin is a chemotherapeutic drug commonly used in the treatment of many childhood solid malignancies. It is known to cause long-term nephrotoxicity, most commonly manifesting as reduced glomerular filtration rate and hypomagnesaemia. Existing literature regarding the epidemiology of long-term nephrotoxicity in childhood cancer describes large variation in prevalence and risk factors.

Objectives

This study is to evaluate the prevalence of, and risk factors for, long-term cisplatin nephrotoxicity after treatment for childhood cancer.

Study eligibility criteria

Studies were eligible for inclusion if they: (i) evaluated participants treated with cisplatin who were diagnosed with cancer < 18 years of age; (ii) investigated any author-defined measure of nephr

SUBMITTER: Schofield J 

PROVIDER: S-EPMC10817831 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature