Associations between anemia and FGF23 in the CKiD study.

ABSTRACT:

Background

Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that plays a central role in chronic kidney disease-mineral bone disorder and is associated with CKD progression and cardiovascular morbidity. Factors related to CKD-associated anemia, including iron deficiency, can increase FGF23 production. This study aimed to assess whether anemia and/or iron deficiency are associated with increased circulating concentrations of FGF23 in the large, well-characterized Chronic Kidney Disease in Children (CKiD) study cohort.

Methods

Hemoglobin concentrations, iron parameters, C-terminal (total) FGF23, intact FGF23, and relevant covariables were measured in cross-sectional analysis of CKiD study subjects.

Results

In 493 pediatric patients with CKD (median [interqu

SUBMITTER: Thomas E 

PROVIDER: S-EPMC10817837 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature