Structural connectome architecture shapes the maturation of cortical morphology from childhood to adolescence.

ABSTRACT: Cortical thinning is an important hallmark of the maturation of brain morphology during childhood and adolescence. However, the connectome-based wiring mechanism that underlies cortical maturation remains unclear. Here, we show cortical thinning patterns primarily located in the lateral frontal and parietal heteromodal nodes during childhood and adolescence, which are structurally constrained by white matter network architecture and are particularly represented using a network-based diffusion model. Furthermore, connectome-based constraints are regionally heterogeneous, with the largest constraints residing in frontoparietal nodes, and are associated with gene expression signatures of microstructural neurodevelopmental events. These results are highly reproducible in another independent da

SUBMITTER: Liang X 

PROVIDER: S-EPMC10817914 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature