"Digital twins elucidate critical role of T_scm in clinical persistence of TCR-engineered cell therapy".

ABSTRACT: Despite recent progress in adoptive T cell therapy for cancer, understanding and predicting the kinetics of infused T cells remains a challenge. Multiple factors can impact the distribution, expansion, and decay or persistence of infused T cells in patients. We have developed a novel quantitative systems pharmacology (QSP) model of TCR-transgenic T cell therapy in patients with solid tumors to describe the kinetics of endogenous T cells and multiple memory subsets of engineered T cells after infusion. These T cells undergo lymphodepletion, proliferation, trafficking, differentiation, and apoptosis in blood, lymph nodes, tumor site, and other peripheral tissues. Using the model, we generated patient-matched digital twins that recapitulate the circulating T cell kinetics reported from a clin

SUBMITTER: Joslyn LR 

PROVIDER: S-EPMC10817974 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature