Systems biology approaches to identify driver genes and drug combinations for treating COVID-19.

ABSTRACT: Corona virus 19 (Covid-19) has caused many problems in public health, economic, and even cultural and social fields since the beginning of the epidemic. However, in order to provide therapeutic solutions, many researches have been conducted and various omics data have been published. But there is still no early diagnosis method and comprehensive treatment solution. In this manuscript, by collecting important genes related to COVID-19 and using centrality and controllability analysis in PPI networks and signaling pathways related to the disease; hub and driver genes have been identified in the formation and progression of the disease. Next, by analyzing the expression data, the obtained genes have been evaluated. The results show that in addition to the significant difference in the express

SUBMITTER: Ebrahimi A 

PROVIDER: S-EPMC10817985 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature