Benchmark dose modeling for epidemiological dose-response assessment using prospective cohort studies.

ABSTRACT: Benchmark dose (BMD) methodology has been employed as a default dose-response modeling approach to determine the toxicity value of chemicals to support regulatory chemical risk assessment. Especially, a relatively standardized BMD analysis framework has been established for modeling toxicological data regarding the formats of input data, dose-response models, definitions of benchmark response, and model uncertainty consideration. However, the BMD approach has not been well developed for epidemiological data mainly because of the diverse designs of epidemiological studies and various formats of data reported in the literature. Although most of the epidemiological BMD analyses were developed to solve a particular question, the methods proposed in two recent studies are able to handle cohort

SUBMITTER: De Pretis F 

PROVIDER: S-EPMC10817999 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature