Exploring gastric cancer genetics: A turning point in common variable immunodeficiency.

ABSTRACT:

Background

Gastric cancer (GC) stands as a prominent cause of cancer-related mortality and ranks second among the most frequently diagnosed malignancies in individuals with common variable immunodeficiency (CVID).

Objective

We sought to conduct a comprehensive, large-scale genetic analysis to explore the CVID-associated germline variant landscape within gastric adenocarcinoma samples and to seek to delineate the transcriptomic similarities between GC and CVID.

Methods

We investigated the presence of CVID-associated germline variants in 1591 GC samples and assessed their impact on tumor mutational load. The progression of GC was evaluated in patients with and without these variants. Transcriptomic similarities were explored by matching differentially expressed genes in

SUBMITTER: Sanchez-Ramon S 

PROVIDER: S-EPMC10818086 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature