The landscape of the methodology in drug repurposing using human genomic data: a systematic review.

ABSTRACT: The process of drug development is expensive and time-consuming. In contrast, drug repurposing can be introduced to clinical practice more quickly and at a reduced cost. Over the last decade, there has been a significant expansion of large biobanks that link genomic data to electronic health record data, public availability of various databases containing biological and clinical information and rapid development of novel methodologies and algorithms in integrating different sources of data. This review aims to provide a thorough summary of different strategies that utilize genomic data to seek drug-repositioning opportunities. We searched MEDLINE and EMBASE databases to identify eligible studies up until 1 May 2023, with a total of 102 studies finally included after two-step parallel scree

SUBMITTER: Wang L 

PROVIDER: S-EPMC10818097 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature