COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history.

ABSTRACT:

Background

The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific T-cells and neutralizing antibodies (nAbs) during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019 (COVID-19). We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb titers.

Methods

Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 vaccine. All major leukocyte subtypes were enumerated before, during, and after exercise by flow cytometry, and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays, T-cell receptor (TCR)-β seque

SUBMITTER: Smith KA 

PROVIDER: S-EPMC10818112 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature