Allogeneic bone marrow transplantation for patients with treatment-refractory Crohn's Disease.

ABSTRACT:

Background & aims

Durable remissions of Crohn's Disease (CD) have followed myeloablative conditioning therapy and allogeneic marrow transplantation. For patients with treatment-refractory disease, we used reduced-intensity conditioning to minimize toxicity, marrow from donors with low Polygenic Risk Scores for CD as cell sources, and protracted immune suppression to lower the risk of graft-versus-host disease (GVHD). Our aim was to achieve durable CD remissions while minimizing transplant-related complications.

Methods

DNA from patients and their HLA-matched unrelated donors was genotyped and Polygenic Risk Scores calculated. Donor marrow was infused following non-myeloablative conditioning. Patient symptoms and endoscopic findings were documented at intervals after transpla

SUBMITTER: McDonald GB 

PROVIDER: S-EPMC10818189 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature