Genetic and brain similarity independently predict childhood anthropometrics and neighborhood socioeconomic conditions.

ABSTRACT: Linking the developing brain with individual differences in clinical and demographic traits is challenging due to the substantial interindividual heterogeneity of brain anatomy and organization. Here we employ an integrative approach that parses individual differences in both cortical thickness and common genetic variants, and assess their effects on a wide set of childhood traits. The approach uses a linear mixed model framework to obtain the unique effects of each type of similarity, as well as their covariance. We employ this approach in a sample of 7760 unrelated children in the ABCD cohort baseline sample (mean age 9.9, 46.8% female). In general, associations between cortical thickness similarity and traits were limited to anthropometrics such as height, weight, and birth weight, as w

SUBMITTER: Dahl A 

PROVIDER: S-EPMC10818201 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature