Analysis of subsets and localization of macrophages in skin lesions and peripheral blood of patients with keloids.

ABSTRACT: Keloids are a type of abnormal fibrous proliferation disease of the skin, characterized by local inflammation that lacks clear pathogenesis and satisfactory treatment. The phenomenon of distinct phenotypes, including M1 and M2 macrophages, is called macrophage polarization. Recently, macrophage polarization has been suggested to play a role in keloid formation. This study aimed to evaluate the relation between macrophage polarization and keloids and identify novel effective treatments for keloids. Differentially expressed genes were identified via RNA sequencing of the skin tissue of healthy controls and patients with keloids and validated using quantitative PCR. Multiplex immunofluorescence microscopy was used to detect different phenotypes of macrophages in keloid tissues. Finally, quant

SUBMITTER: Lv X 

PROVIDER: S-EPMC10818209 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature