Pruritus and protein-bound uremic toxins in patients undergoing hemodialysis: a cross-sectional study.

ABSTRACT:

Background

Patients undergoing hemodialysis frequently experience pruritus; its severity is associated with poor quality of life and mortality. Recent progress in hemodialysis treatment has improved the removal of small- and middle-molecular-weight molecules; however, the removal of protein-bound uremic toxins (PBUTs) remains difficult. It is possible that pruritus is associated with serum PBUTs in patients undergoing hemodialysis.

Methods

We conducted a multicenter cross-sectional study in patients undergoing hemodialysis (n = 135). The severity of pruritus was assessed using the 5D-itch scale and medication use. Serum PBUTs, including indoxyl sulfate, p-cresyl sulfate, indole acetic acid, phenyl sulfate, and hippuric acid, were measured using mass spectrometry; the

SUBMITTER: Yamamoto S 

PROVIDER: S-EPMC10818225 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature