Paracrine Signaling Mediated by the Cytosolic Tryparedoxin Peroxidase of <i>Trypanosoma cruzi</i>.

ABSTRACT: Peroxiredoxins are abundant and ubiquitous proteins that participate in different cellular functions, such as oxidant detoxification, protein folding, and intracellular signaling. Under different cellular conditions, peroxiredoxins can be secreted by different parasites, promoting the induction of immune responses in hosts. In this work, we demonstrated that the cytosolic tryparedoxin peroxidase of Trypanosoma cruzi (cTXNPx) is secreted by epimastigotes and trypomastigotes associated with extracellular vesicles and also as a vesicle-free protein. By confocal microscopy, we show that cTXNPx can enter host cells by an active mechanism both through vesicles and as a recombinant protein. Transcriptomic analysis revealed that cTXNPx induces endoplasmic reticulum stress and interleukin-8

SUBMITTER: Chiribao ML 

PROVIDER: S-EPMC10818299 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature