Is Gender an Important Factor in the Precision Medicine Approach to Levocetirizine?

ABSTRACT: Currently, there is insufficient information on the variability in levocetirizine pharmacometrics among individuals, a crucial aspect for establishing its clinical use. The gender differences in pharmacokinetics and the extent of variation in pharmacodynamics have not been definitively identified. The primary goal of this study was to investigate gender differences in levocetirizine pharmacokinetics and quantitatively predict and compare how these gender-related pharmacokinetic differences impact pharmacodynamics, using population pharmacokinetic-pharmacodynamic modeling. Bioequivalence results for levocetirizine (only from the control formulation) were obtained from both healthy Korean men and women. Physiological and biochemical parameters for each individual were utilized as pharmacokin

SUBMITTER: Jeong SH 

PROVIDER: S-EPMC10818372 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature