Affinity-Based Magnetic Nanoparticle Development for Cancer Stem Cell Isolation.

ABSTRACT: Cancer is still the leading cause of death in the world despite the developing research and treatment opportunities. Failure of these treatments is generally associated with cancer stem cells (CSCs), which cause metastasis and are defined by their resistance to radio- and chemotherapy. Although known stem cell isolation methods are not sufficient for CSC isolation, they also bring a burden in terms of cost. The aim of this study is to develop a high-efficiency, low-cost, specific method for cancer stem cell isolation with magnetic functional nanoparticles. This study, unlike the stem cell isolation techniques (MACS, FACS) used today, was aimed to isolate cancer stem cells (separation of CD133⁺ cells) with nanoparticles with specific affinity and modification properties. For this

SUBMITTER: Kuru CI 

PROVIDER: S-EPMC10818538 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature