Ruthenium-Cyclopentadienyl-Cycloparaphenylene Complexes: Sizable Multicharged Cations Exhibiting High DNA-Binding Affinity and Remarkable Cytotoxicity.

ABSTRACT: Two novel sizable multicharged cationic complexes, of the formulae [(η⁶--[12]CPP)[Ru(η⁵--Cp)]₁₂]Χ₁₂ and [(η⁶--[11]CPP)[Ru(η⁵--Cp)]₁₁]Χ₁₁, CPP = cycloparaphenylene, Cp = cyclopentadienyl, X = [PF₆]^-, (1), (3) and [Cl]^-, (2), (4), were synthesized and characterized using NMR techniques, high-resolution mass spectrometry, and elemental analyses. Complexes (1) and (3) were stable in acetone and acetonitrile solutions over 48 h. In contrast, the water-soluble (2) and (4) begin to decompose in aqueous media after 1 h, due to the [Cl]^- tendency for nucleophilic attack on ruthenium of

SUBMITTER: Ypsilantis K 

PROVIDER: S-EPMC10818589 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature