Photodynamic Inactivation of Bovine Coronavirus with the Photosensitizer Toluidine Blue O.

ABSTRACT: Coronaviruses (CoVs) belong to the group of enveloped positive-sense single-strand RNA viruses and are causative agents of respiratory, gastro-intestinal, and central nervous systems diseases in many host species, i.e., birds, mammals, and humans. Beta-CoVs revealed a great potential to cross the barrier between species by causing three epidemics/pandemics among humans in the 21st century. Considering the urgent need for powerful antiviral agents for decontamination, prevention, and treatment of BCoV infections, we turned our attention to the possibility of photodynamic inactivation with photosensitizers in combination with light irradiation. In the present study, we evaluated, for the first time, the antiviral activity of toluidine blue O (TBO) against Beta-coronavirus 1 (BCoV) in compari

SUBMITTER: Zaharieva MM 

PROVIDER: S-EPMC10818719 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature