Evidence of Differences in Cellular Regulation of <i>Wolbachia</i>-Mediated Viral Inhibition between Alphaviruses and Flaviviruses.

ABSTRACT: The intracellular bacterium Wolbachia is increasingly being utilised in control programs to limit the spread of arboviruses by Aedes mosquitoes. Achieving a better understanding of how Wolbachia strains can reduce viral replication/spread could be important for the long-term success of such programs. Previous studies have indicated that for some strains of Wolbachia, perturbations in lipid metabolism and cholesterol storage are vital in Wolbachia-mediated antiviral activity against the flaviviruses dengue and Zika; however, it has not yet been examined whether arboviruses in the alphavirus group are affected in the same way. Here, using the reporters for the alphavirus Semliki Forest virus (SFV) in Aedes albopictus cells, we found that Wolbachia

SUBMITTER: Rainey SM 

PROVIDER: S-EPMC10818798 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature