Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress.

ABSTRACT: Using co-amorphous systems (CAMS) has shown promise in addressing the challenges associated with poorly water-soluble drugs. Quench-cooling is a commonly used CAMS preparation method, often followed by grinding or milling to achieve a fine powder that is suitable for subsequent characterization or further down-stream manufacturing. However, the impact of mechanical stress applied to CAMS has received little attention. In this study, the influence of mechanical stress on indomethacin-paracetamol CAMS was investigated. The investigation involved thermal analysis and solid-state characterization across various CAMS mixing ratios and levels of mechanical stress. The study revealed a negative effect of mechanical stress on stability, particularly on the excess components in CAMS. Higher levels

SUBMITTER: Di R 

PROVIDER: S-EPMC10818836 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature