Neutralizing Antibody Response following a Third Dose of the mRNA-1273 Vaccine among Cancer Patients.

ABSTRACT: Cancer patients are at an increased risk of morbidity and mortality from SARS-CoV-2 infection and have a decreased immune response to vaccination. We conducted a study measuring both the neutralizing and total antibodies in cancer patients following a third dose of the mRNA-1273 COVID-19 vaccine. Immune responses were measured with an enzyme-linked immunosorbent assay (ELISA) and neutralization assays. Kruskal-Wallis tests were used to evaluate the association between patient characteristics and neutralization geometric mean titers (GMTs), and paired t-tests were used to compare the GMTs between different timepoints. Spearman correlation coefficients were calculated to determine the correlation between total antibody and neutralization GMTs. Among 238 adults diagnosed with cancer, a

SUBMITTER: Dukes CW 

PROVIDER: S-EPMC10818923 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature