Solid Lipid Nanoparticles Enhancing the Leishmanicidal Activity of Delamanid.

ABSTRACT: Leishmaniasis, a zoonotic parasitic disease transmitted by infected sandflies, impacts nearly 1 million people yearly and is endemic in many countries across Asia, Africa, the Americas, and the Mediterranean; despite this, it remains a neglected disease with limited effective treatments, particularly in impoverished communities with limited access to healthcare. This study aims to repurpose approved drugs for an affordable leishmaniasis treatment. After the screening of potential drug candidates by reviewing databases and utilizing molecular docking analysis, delamanid was chosen to be incorporated into solid lipid nanoparticles (SLNPs). Both in cellulo and in vivo tests confirmed the successful payload release within macrophages and through the epidermis following topical application on m

SUBMITTER: Santamaria-Aguirre J 

PROVIDER: S-EPMC10818933 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature