Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer.

ABSTRACT: Histone deacetylase 6 (HDAC6), by deacetylation of multiple substrates and association with interacting proteins, regulates many physiological processes that are involved in cancer development and invasiveness such as cell proliferation, apoptosis, motility, epithelial to mesenchymal transition, and angiogenesis. Due to its ability to remove misfolded proteins, induce autophagy, and regulate unfolded protein response, HDAC6 plays a protective role in responses to stress and enables tumor cell survival. The scope of this review is to discuss the roles of HDCA6 and its implications for the therapy of colorectal cancer (CRC). As HDAC6 is overexpressed in CRC, correlates with poor disease prognosis, and is not essential for normal mammalian development, it represents a good therapeutic target.

SUBMITTER: Vuletic A 

PROVIDER: S-EPMC10818982 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature