Methamphetamine Shows Different Joint Toxicity for Different Types of Microplastics on Zebrafish Larvae by Mediating Oxidative Stress.

ABSTRACT: The coexistence of polystyrene (PS) and polypropylene (PVC) microplastics (MPs) and methamphetamine (METH) in aquatic systems is evident. However, the joint toxicity is unclear. Here, zebrafish larvae were exposed to single PS and PVC MPs (20 mg L^-1) and combined with METH (250 and 500 μg L^-1) for 10 days. The results indicated that acute exposure to PS and PVC MPs induced lethal effects on zebrafish larvae (10-20%). Treatment with MPs markedly suppressed the locomotion of zebrafish, showing as the lengthy immobility (51-74%) and lower velocity (0.09-0.55 cm s^-1) compared with the control (1.07 cm s^-1). Meanwhile, histopathological analysis revealed pronounced depositions of MPs particles in fish's intestinal tract, triggering inflammatory respon

SUBMITTER: Xu J 

PROVIDER: S-EPMC10819112 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature