Targeting one-carbon metabolism for cancer immunotherapy.

ABSTRACT:

Background

One-carbon (1C) metabolism is a metabolic network that plays essential roles in biological reactions. In 1C metabolism, a series of nutrients are used to fuel metabolic pathways, including nucleotide metabolism, amino acid metabolism, cellular redox defence and epigenetic maintenance. At present, 1C metabolism is considered the hallmark of cancer. The 1C units obtained from the metabolic pathways increase the proliferation rate of cancer cells. In addition, anticancer drugs, such as methotrexate, which target 1C metabolism, have long been used in the clinic. In terms of immunotherapy, 1C metabolism has been used to explore biomarkers connected with immunotherapy response and immune-related adverse events in patients.

Methods

We collected numerous literatures to ex

SUBMITTER: Ren X 

PROVIDER: S-EPMC10819114 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature