Reclassification of ASFV into 7 Biotypes Using Unsupervised Machine Learning.

ABSTRACT: In 2007, an outbreak of African swine fever (ASF), a deadly disease of domestic swine and wild boar caused by the African swine fever virus (ASFV), occurred in Georgia and has since spread globally. Historically, ASFV was classified into 25 different genotypes. However, a newly proposed system recategorized all ASFV isolates into 6 genotypes exclusively using the predicted protein sequences of p72. However, ASFV has a large genome that encodes between 150-200 genes, and classifications using a single gene are insufficient and misleading, as strains encoding an identical p72 often have significant mutations in other areas of the genome. We present here a new classification of ASFV based on comparisons performed considering the entire encoded proteome. A curated database consisting of the pr

SUBMITTER: Dinhobl M 

PROVIDER: S-EPMC10819123 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature