Development of Pleiotropic TrkB and 5-HT₄ Receptor Ligands as Neuroprotective Agents.

ABSTRACT: One common event that is the most detrimental in neurodegenerative disorders, even though they have a complex pathogenesis, is the increased rate of neuronal death. Endogenous neurotrophins consist of the major neuroprotective factors, while brain-derived neurotrophic factor (BDNF) and its high-affinity tyrosine kinase receptor TrkB are described in a number of studies for their important neuronal effects. Normal function of this receptor is crucial for neuronal survival, differentiation, and synaptic function. However, studies have shown that besides direct activation, the TrkB receptor can be transactivated via GPCRs. It has been proven that activation of the 5-HT₄ receptor and transactivation of the TrkB receptor have a positive influence on neuronal differentiation (total de

SUBMITTER: Antonijevic M 

PROVIDER: S-EPMC10819171 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature