Reliability of Time-Series Plasma Metabolome Data over 6 Years in a Large-Scale Cohort Study.

ABSTRACT: Studies examining long-term longitudinal metabolomic data and their reliability in large-scale populations are limited. Therefore, we aimed to evaluate the reliability of repeated measurements of plasma metabolites in a prospective cohort setting and to explore intra-individual concentration changes at three time points over a 6-year period. The study participants included 2999 individuals (1317 men and 1682 women) from the Tsuruoka Metabolomics Cohort Study, who participated in all three surveys-at baseline, 3 years, and 6 years. In each survey, 94 plasma metabolites were quantified for each individual and quality control (QC) sample. The coefficients of variation of QC, intraclass correlation coefficients, and change rates of QC were calculated for each metabolite, and their reliability

SUBMITTER: Miyake A 

PROVIDER: S-EPMC10819202 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature