Effects of Soy Protein Isolate on Fragile X Phenotypes in Mice.

ABSTRACT: Obesity is a pediatric epidemic that is more prevalent in children with developmental disabilities. We hypothesize that soy protein-based diets increase weight gain and alter neurobehavioral outcomes. Our objective herein was to test matched casein- and soy protein-based purified ingredient diets in a mouse model of fragile X syndrome, Fmr1^KO mice. The experimental methods included assessment of growth; 24-7 activity levels; motor coordination; learning and memory; blood-based amino acid, phytoestrogen and glucose levels; and organ weights. The primary outcome measure was body weight. We find increased body weight in male Fmr1^KO from postnatal day 6 (P6) to P224, male wild type (WT) from P32-P39, female Fmr1^KO from P6-P18 and P168-P224,

SUBMITTER: Westmark PR 

PROVIDER: S-EPMC10819477 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature