Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood.

ABSTRACT: Prostate cancer is the second leading cause of cancer death in men in the United States. Androgen deprivation therapy (ADT) is currently the primary treatment for metastatic prostate cancer, and some studies have shown that the use of anti-androgen drugs is related to a reduction in cognitive function, mood changes, diminished quality of life, dementia, and possibly Alzheimer's disease. ADT has potential physiological effects such as a reduction in white matter integrity and a negative impact on hypothalamic functions due to the lowering of testosterone levels or the blockade of downstream androgen receptor signaling by first- and second-generation anti-androgen drugs. A comparative analysis of prostate cancer patients undergoing ADT and Alzheimer patients identified over 30 shared genes,

SUBMITTER: Reiss AB 

PROVIDER: S-EPMC10819522 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature