An In Silico Investigation of the Molecular Interactions between Volatile Anesthetics and Actin.

ABSTRACT: Volatile anesthetics (VAs) are medicinal chemistry compounds commonly used to enable surgical procedures for patients who undergo painful treatments and can be partially or fully sedated, remaining in an unconscious state during the operation. The specific molecular mechanism of anesthesia is still an open issue, but scientific evidence supports the hypothesis of the involvement of both putative hydrophobic cavities in membrane receptors as binding pockets and interactions between anesthetics and cytoplasmic proteins. Previous studies demonstrated the binding of VAs to tubulin. Since actin is the other major component of the cytoskeleton, this study involves an investigation of its interactions with four major anesthetics: halothane, isoflurane, sevoflurane, and desflurane. Molecular docki

SUBMITTER: Truglia B 

PROVIDER: S-EPMC10819646 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature