Role of the Bacterial Amyloid-like Hfq in Fluoroquinolone Fluxes.

ABSTRACT: Due to their two-cell membranes, Gram-negative bacteria are particularly resistant to antibiotics. Recent investigations aimed at exploring new target proteins involved in Gram-negative bacteria adaptation helped to identify environmental changes encountered during infection. One of the most promising approaches in finding novel targets for antibacterial drugs consists of blocking noncoding RNA-based regulation using the protein cofactor, Hfq. Although Hfq is important in many bacterial pathogens, its involvement in antibiotics response is still unclear. Indeed, Hfq may mediate drug resistance by regulating the major efflux system in Escherichia coli, but it could also play a role in the influx of antibiotics. Here, using an imaging approach, we addressed this problem quantitatively

SUBMITTER: Turbant F 

PROVIDER: S-EPMC10819720 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature