Meltdose Tacrolimus Population Pharmacokinetics and Limited Sampling Strategy Evaluation in Elderly Kidney Transplant Recipients.

ABSTRACT:

Background

Meltdose tacrolimus (Envarsus^®) has been marketed as a formulation achieving a more consistent tacrolimus exposure. Due to the narrow therapeutic window of tacrolimus, dose individualization is essential. Relaxation of the upper age limits for kidney transplantations has resulted in larger numbers of elderly patients receiving tacrolimus. However, due to the physiological changes caused by aging, the tacrolimus pharmacokinetics (PK) might be altered. The primary aim was to develop a population PK model in elderly kidney transplant recipients. Secondary aims were the development and evaluation of a limited sampling strategy (LSS) for AUC estimation.

Methods

A total of 34 kidney transplant recipients aged ≥65 years, starting on meltdose tacrolimus directl

SUBMITTER: Kamp J 

PROVIDER: S-EPMC10819724 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature