Metabolomic Changes in Rat Serum after Chronic Exposure to Glyphosate-Based Herbicide.

ABSTRACT: Glyphosate-based herbicides (GBHs) have gained extensive popularity in recent decades. For many years, glyphosate has been regarded as harmless or minimally toxic to mammals due to the absence of its primary target, the shikimic acid pathway in humans. Nonetheless, mounting evidence suggests that glyphosate may cause adverse health effects in humans via other mechanisms. In this study, we described the metabolomic changes in the serum of experimental rats exposed to chronic GBH using the highly sensitive LC-MS/MS technique. We investigated the possible relationship between chronic exposure to GBH and neurological disorders. Our findings suggest that chronic exposure to GBH can alter spatial learning memory and the expression of some important metabolites that are linked to neurophysiologic

SUBMITTER: Daramola O 

PROVIDER: S-EPMC10819816 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature