Diversity and Evolutionary Analysis of Venom Insulin Derived from Cone Snails.

ABSTRACT: Cone snails possess a diverse array of novel peptide toxins, which selectively target ion channels and receptors in the nervous and cardiovascular systems. These numerous novel peptide toxins are a valuable resource for future marine drug development. In this review, we compared and analyzed the sequence diversity, three-dimensional structural variations, and evolutionary aspects of venom insulin derived from different cone snail species. The comparative analysis reveals that there are significant variations in the sequences and three-dimensional structures of venom insulins from cone snails with different feeding habits. Notably, the venom insulin of some piscivorous cone snails exhibits a greater similarity to humans and zebrafish insulins. It is important to emphasize that these venom i

SUBMITTER: Guo Q 

PROVIDER: S-EPMC10819828 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature