High-Degree Concentration Organic Solvent Forward Osmosis for Pharmaceutical Pre-Concentration.

ABSTRACT: Over half of the pharmaceutical industry's capital investments are related to the purification of active pharmaceutical ingredients (APIs). Thus, a cost-effective purification process with a highly concentrated solution is urgently required. In addition, the purification process should be nonthermal because most APIs and their intermediates are temperature-sensitive. This study investigated a high-degree concentration organic solvent forward osmosis (OSFO) membrane process. A polyketone-based thin-film composite hollow fiber membrane with a polyamide selective layer on the bore surface was used as the OSFO membrane to achieve a high tolerance for organic solvents and an effective concentration. MeOH, sucrose octaacetate (SoA), and 2M polyethylene glycol 400 (PEG-400)/MeOH solution were use

SUBMITTER: Takada R 

PROVIDER: S-EPMC10819892 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature