Gemcitabine-Vitamin E Prodrug-Loaded Micelles for Pancreatic Cancer Therapy.

ABSTRACT: Pancreatic cancer (PC) is an aggressive cancer subtype presenting unmet clinical challenges. Conventional chemotherapy, which includes antimetabolite gemcitabine (GEM), is seriously undermined by a short half-life, its lack of targeting ability, and systemic toxicity. GEM incorporation in self-assembled nanosystems is still underexplored due to GEM's hydrophilicity which hinders efficient encapsulation. We hypothesized that vitamin E succinate-GEM prodrug (VES-GEM conjugate) combines hydrophobicity and multifunctionalities that can facilitate the development of Pluronic^® F68 and Pluronic^® F127 micelle-based nanocarriers, improving the therapeutic potential of GEM. Pluronic^® F68/VES-GEM and Pluronic^® F127/VES-GEM micelles covering a wide range of

SUBMITTER: Pereira-Silva M 

PROVIDER: S-EPMC10819901 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature