Anti-Proliferative and Apoptotic Activities of Rumex crispus.

ABSTRACT: Colorectal cancer is the fourth leading cause of cancer death and the third most common cancer diagnosed in the United States. Several anticancer compounds from natural products have been of great interest in cancer chemotherapy and are currently in clinical trials. Natural products that present the targeted killing of cancerous cell and are soluble in water with minimal side effects are ideal candidates. In this study, water-soluble compounds from Rumex crispus plants were screened for anti-proliferative and apoptotic activity against human colorectal adenocarcinoma (DLD-1) cells. The most potent fraction with the highest cell killing and caspase fold change rates was selected for further experiments. The observed changes were further validated by measuring the caspase fold change

SUBMITTER: Mohammadhosseinpour S 

PROVIDER: S-EPMC10819952 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature