Polyamine Metabolism for Drug Intervention in Trypanosomatids.

ABSTRACT: Neglected tropical diseases transmitted by trypanosomatids include three major human scourges that globally affect the world's poorest people: African trypanosomiasis or sleeping sickness, American trypanosomiasis or Chagas disease and different types of leishmaniasis. Different metabolic pathways have been targeted to find antitrypanosomatid drugs, including polyamine metabolism. Since their discovery, the naturally occurring polyamines, putrescine, spermidine and spermine, have been considered important metabolites involved in cell growth. With a complex metabolism involving biosynthesis, catabolism and interconversion, the synthesis of putrescine and spermidine was targeted by thousands of compounds in an effort to produce cell growth blockade in tumor and infectious processes with limi

SUBMITTER: Perez-Pertejo Y 

PROVIDER: S-EPMC10820115 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature