A Facile Ugi/Ullmann Cascade Reaction to Access Fused Indazolo-Quinoxaline Derivatives with Potent Anticancer Activity.

ABSTRACT: A facile methodology for the construction of a complex heterocycle indazolo-fused quinoxalinone has been developed via an Ugi four-component reaction (U-4CR) followed by an intramolecular Ullmann reaction. The expeditious process features an operationally simple approach, time efficiency, and a broad substrate scope. Biological activity was evaluated and demonstrated that compound 6e inhibits human colon cancer cell HCT116 proliferation with an IC₅₀ of 2.1 μM, suggesting potential applications for developing a drug lead in medicinal chemistry.

SUBMITTER: Li Y 

PROVIDER: S-EPMC10820152 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature